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    PREDICTIONS

    Will Living to 200 years old be tiny or huge by 2030

    Will Living to 200 years old be tiny or huge by 2030?

    Meet Laura Deming, Founder of The Longevity Fund. She is on a mission to transform our understanding and treatment of aging and life expectancy.

    And meet Aisha a 20 year old who wants to live to 200 years old.

    In this article, I predict how huge Living to 200 years old will be by 2030 on a scale of 1 to 10 based on looking at:

    • The technology needed
    • The companies making it happen
    • What's to love
    • jobs that will be hired.

    Technology

    Living to 200 years old will be huge if the four major technology challenges are solved.

    Remove zombie cells

    As Aisha gets older, zombie cells - known as senescent cells - accumulate causing damage to vital tissues leading to disease and death.

    Laura and longevity researchers are putting huge amounts of effort into finding the chainsaw that will kill off these zombies.

    The mouse on the right is the same age as the mouse on the left but clearly looks younger and lived 30% longer.  Amazing.

    Remove zombie cells


    Senolytics is the name given to the class of treatments in humans that terminate these zombie cells. One way Laura and others are tackling zombie cells is by trying out stem cell treatments.She is also testing using existing natural occurring compounds like Fisetin -found in strawberries and apples - and using blood plasma treatments.

    Harness young blood

    As Aisha gets older she moves from having 'young blood' that is effective at regenerating cells and keeping diseases such as Alzheimers at bay to 'old blood' that has a lower concentration of what's needed.

    Laura and aging researchers are putting effort into understanding young blood and building related treatments.

    They have shown that mice injected with young blood plasma remain healthier and live longer. The GDF-11 molecule is the focus of the technological approaches being tried. This molecule has been shown to be in higher concentrations in young blood. When GDF-11 is injected into older mice it strengthens their heart and restores aging brain and muscle function.
    But don't try this at home folks. The San Francisco startup, Ambrosia, sells transfusions of young blood at a cost of $8000 for 2 liters. The US Food and Drug Administration in 2019, issued a warning against transfusion services like Ambrosia's referencing as yet unproven benefits and safety issues.

    Harness young blood

    Refuel cells

    Every 20 years, Aisha has half the level of one essential natural fuel that every cell relies on called NAD+. This helps keep tiredness and aging at bay. TruNiagen is one of the supplements available today to counteract this.This treatment is part of a booming industry in life extending supplements that have varying degrees of scientific proof.
    This guy, Dave Asprey, claims he will live to at least 180 years old through the supplements he takes.

    Dave Asprey

    Treat all aging process

    For Aisha to live to 200 years old, she needs to not only treat her senescent zombie cells but stop or reverse 9 changes occurring in her body that scientists have identified cause aging.  

    Cellular Senesence
    Intercellular Communication
    Genomic Instability
    Telomere Attrition
    Epigenetic Alteration
    Proteostasis Loss
    Nutrient Sensing
    Mitochondrial Dysfunction
    Cell Exhaustion

    Laura and scientists like Aubrey de Grey, a pioneer in this field who has dedicated his life to reversing aging, are hard at work on all of these with a total of 59 treatments in development today at the time of recording with this many per aging process shown here.

    9 Aging processes in your body

    Companies

    Living to 200 years old will be huge if there are unicorns -  startup companies that have a valuation of more than a billion dollars and when there's plenty of big established companies.

    The Longevity Fund

    Laura's company, The Longevity Fund, is an investor in the sector. She founded her venture capital firm 10 years ago when she was an unbelievably young 17 years old! She has been wanting to cure aging since aged 8, was studying physics at MIT at 14, and dropped out to complete a Thiel Fellowship that funds students to "build new things" rather than complete their studies. She's invested in more than 10 longevity startups some of them might already be unicorns.

    BioAge

    BioAge is a startup on its way to being a unicorn. Kristen Fortney founded the company in 2015. She is working with 45 years worth of patient blood samples together with AI to identify molecular drivers of aging and develop treatments. One initiative of BioAge is aiming to activate HIF target genes. These genes are involved in several aging processes.

    Elevian

    Elevian is an aspiring unicorn that Laura invested in last year.

    It's spun out of the Harvard Department of Stem Cell and Regenerative Biology with an initial focus to develop medicines that restore the body's youthful regenerative capacity including the use of GPF-11

    There’s plenty of multinational companies that are active including Google, Abbvie and Taisho.

    Investing heavily
    Google has created and invested heavily in its life sciences moonshot, Calico.
    Its innovations include building customised robots to massively accelerate the throughput of lab work. It was founded by Bill Maris, who started Google Ventures.

    Partnering
    Multinationals are also partnering. Abbvie, the big pharmaceutical company, recently announced a billion dollar partnership with Calico to develop anti-aging drugs.

    Licensing treatments

    Licencing treatments from startups is popular. The Japanese pharmaceutical giant, Taisho, for example, has an exclusive licence with BioAge to commercialise and develop its HIF inhibitor. Although there are plenty of startups but many not yet proven

    Love

    Now we look at whether you and I will be giving 5 star levels of love to living 200 years old just as we do to breakthrough cancer treatments.

    Healthier Life

    It gets 5 stars for delivering a healther life if scientists really crack this.
    Today, much as Aisha would like, she can't avoid the fact that as she gets older she is at higher risk of Alzheimer's and a multitude of age-related diseases.

    In 2030, Aisha takes Laura's longevity wonder drugs. This not only dramatically slows the aging process but means Aisha looks and feels younger.
    What is amazing is that when she's, for example, 120 years old she going to look (perhaps) no more than 40! And many age-related diseases are a thing of the past for Aisha and her friends.

    Personal Relationships

    The impact on personal relationships is not necessarily all good news and so gets a 3 stars.


    Today, Aisha hopes to be happily married like her parents for more than 30 years.
    In 2030, taking Laura's wonder drugs, causes Aisha and her friends to spend hours wondering about questions like...
    ....what's it going to be like married for 150 years...Or will I have many marriages over the next century?
    ...Will I have children over the course of the next hundred years? With a huge age gap between siblings?
    ... and "friends for life" will mean for a lot, lot longer.


    I highly recommend looking up online the script of a play by Dr Andrew Harrison that does a brilliant job of bringing all these issues alive.

    Working Life

    Laura's longevity treatments have a massive impact on working life too and only gets 3 stars
    Today, Aisha has an eye on getting her boss's job one day and plans to retire at 70 or earlier.
    In 2030, on Laura's anti-aging treatments, Aisha's asking herself...

    "When do I get promoted?" My boss, Ali, is going to live for another 100 years before he retires, "I can't wait THAT long to get his job!"
    "how often will I have to retrain?" because the world is changing quickly, will I have to have totally new careers several times.
    And she's also wondering if retirement ages will change?  to 100? 150?

    Societal changes

    Societal changes will be big and unpredictable hence it gets 2 stars.

    Laura's wonder drugs causes Aisha to see that there is going to be a big shift in the demographic age structure.
    There are going to be far more older people, and maybe an increase in total population from people living longer if the birth rate doesn't decline.
    Aisha wonders how living to 200 will change society?

    1. WIll politics shift to the right, as older people tend to  vote more conservatively?
    2. Who is going to pay for all this? Pensions? Health costs
    3. How will planet Earth support all the extra people living longer?

    Jobs

    If air taxis are going to be huge there will be lots of jobs hired and fired.

    Doctors and Nurses will one day be fired because people will live longer, healthier lives.

    On the hired side, there are some job vacancies listed on LinkedIn at the time of recording for BioAge

    These include in:Research,QA, Clinical Trial, Gerontologists, Statistics, Finance,HR.It's well worth looking at LinkedIn if you're interested in getting a job in the Longevity sector. Helping you make good career decisions is a big reason why I'm doing this Life in 2030 channel.Jobs in fast growing new sectors like Longevity are exciting and more secure than in older sectors. I was fortunate to join the e-commerce sector with eBay in its early days and have benefited ever since.Jobs in the sector are all around the world. Bioage are headquartered in the Canada. Elevian is in the Boston. The Longevity fund is in SF

    You could set up some job alerts for these companies. It's easy to do on LinkedIn and click to have a look at my 'Finding great jobs for life in 2030' video. Because there are jobs being hired and fired, but currently at a low level, from a Jobs perspective living to 200 years old is on the small end of the scale.

    Prediction

    Now we've covered all four sections, it's time to make a prediction.

    We've seen the technology needed maybe solved.

    there are interesting companies but no unicorns yet.

    Living to 200 years old gets an overall 3 star rating.

    Few jobs are being hired today

    On a scale of 1 to 10, air taxis are around the middle of the scale by 2030 at a 2.

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